Collagen for Joint / Bone Support

It has been suggested that hydrolysed collagen stimulates chondrocyte production, which is involved in the biosynthesis of type II collagen, essential to new cartilage formation.
Osteoarthritis (OA) is the most common form of age-related disease in people aged 65 and older.

It is a degenerative joint disease characterised by the breakdown of joint articular cartilage, triggering pain, stiffness and swelling.

Rheumatoid arthritis (RA) is an autoimmune disease different from OA. In fact, the immune system attacks the body’s own

tissue as though it were a foreign invader.

People with RA produce rheumatoid factor, an immunity-related

substance that targets the synovial membrane (protective layer that encases joints). The consequences are severe pain and inflammation, joint pain and loss of joint movement & functions.

Clinical studies have shown that hydrolysed collagen targets and has a positive effect on joint tissue 1, 2, 3,4, 7.

Daily supplements of 6-10 g of hydrolysed collagen are generally admitted to reduce pain and improve mobility when use with complementary ingredients.

Oesser S et al (1999) : Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Nutrient matabolism 129, 1891-1895.
• Oesser S Seifert J. (2003): Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cutured with degraded collagen. Cell Tissue Res. 311 (3) : 393-9.
• Deal Cl, Moskowitz RW (1999): Nutraceuticals as therapetic agents in osteoarthritis. The role of glycosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 25 (2) : 379-95

• Moskowitz RW (2000): Role of Collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum.. 30 (2) : 87-99.

• Takeda et al 1982 (1982) : ACute and subacute toxicity studies on collageb wound dressing (CAS) in mice and rats. J Toxicol Sci. 7 (2): 63-91.

• Pesakova V, Stol M, Adam M. (1990) : Comparison of the influence of gelatine and collagen substrates on growth of chondrocytes. Folia Biol. 36 (5): 264-70.

• Novotna et al. (1991): The role of cartilage minor collagens in inducing arthritis. Z. Rheumato. 50 (2): 93-8.

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